Literature summary for 3.4.21.106 extracted from

Guipponi, M.; Tan, J.; Cannon, P.Z.; Donley, L.; Crewther, P.; Clarke, M.; Wu, Q.; Shepherd, R.K.; Scott, H.S.
Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss (2007), Am. J. Pathol., 171, 608-616.

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Application

Application	Comment	Organism
medicine	TMPRSS1 is required for normal auditory function	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	Tmprss1-null mice exhibit profound hearing loss with elevated hearing thresholds compared with their heterozygous and wild-type littermates. Cochleae show abnormal tectorial membrane development, reduction in fiber compaction in the peripheral portion of the auditory nerve, and decreased expression of the myelin proteins myelin basic protein and myelin protein zero. Reduced level of the large conductance voltage- and Ca2+-activated K+ channel in the sensory hair cells. Significantly reduced free thyroxine levels	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
TMPRSS1	-	Mus musculus
type II transmembrane serine protease	-	Mus musculus

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Release 2023.1 (January 2023)